The role of Arctic amplification, including observed decreases in sea ice concentration, thickness, and extent, with potential for exciting downstream atmospheric responses in the mid-latitudes, is a timely issue. We identify the role of the regionality of autumn sea ice loss on downstream mid-latitude responses using engineering methodologies adapted to climate modeling, which allow for multiple Arctic sea regions to be perturbed simultaneously. We evaluate downstream responses in various climate fields (e.g., temperature, precipitation, cloud cover) associated with perturbations in the Beaufort/Chukchi Seas and the Kara/Barents Seas. Simulations suggest that the United States response is primarily linked to sea ice changes in the Beaufort/Chukchi Seas, whereas Eurasian response is primarily due to Kara/Barents sea ice coverage changes. Downstream effects are most prominent approximately 6-10 weeks after the initial perturbation (sea ice loss). Our findings suggest that winter mid-latitude storms (connected to the so-called “Polar Vortex”) are linked to sea ice loss in particular areas, implying that further sea ice loss associated with climate change will exacerbate these types of extreme events.