This presentation will report on the findings of recent modeling studies and a series of workshops and other efforts convened under the auspices of the US Global Change Research Program (USGCRP) to improve integration of critical infrastructure, natural resources, integrated assessment, and human systems modeling. The focus is issues related to drought and increased variability of water supply at the energy-water-land nexus. One motivation for the effort is the potential for impact cascades across coupled built, natural, and socioeconomic systems stressed by social and environmental change. The design is for an adaptable modeling framework that will includes a repository of independently-developed modeling tools of varying complexity – from coarser grid, longer time-horizon to higher-resolution shorter-term models of socioeconomic systems, infrastructure, and natural resources. The models draw from three interlocking research communities: Earth system, impacts/adaptation/vulnerability, and integrated assessment. A key lesson will be explored, namely the importance of defining a clear use perspective to limit dimensionality, focus modeling, and facilitate uncertainty characterization and communication.