Both Earth and human systems exert notable controls on streamflow and stream temperature that influence energy production and ecosystem health. An integrated water model representing river processes and reservoir regulations has been developed and coupled to a land surface model and an integrated assessment model of energy, land, water, and socioeconomics to investigate the energy-water-ecology nexus in the context of climate change and water management. Simulations driven by two climate change projections following the RCP 4.5 and RCP 8.5 radiative forcing scenarios, with and without water management, are analyzed to evaluate the individual and combined effects of climate change and water management on streamflow and stream temperature in the U.S. The simulations revealed important impacts of climate change and water management on hydrological droughts. The simulations also revealed the dynamics of competition between changes in water demand and water availability in the RCP 4.5 and RCP 8.5 scenarios that influence streamflow and stream temperature, with important consequences to thermoelectricity production and future survival of juvenile Salmon. The integrated water model is being implemented to the Accelerated Climate Modeling for Energy (ACME), a coupled Earth System Model, to enable future investigations of the energy-water-ecology nexus in the integrated Earth-Human system.