We applied a linear framework to quantify the response of tropical marine low clouds to ascent area sea surface temperature (SST) changes from both observations and CMIP6 models. The strength of this teleconnection is crucial to the SST pattern effect during global warming, and it is regulated by the weak temperature gradient in the deep tropics. During the recent decades and in pre-industrial control (piControl) simulations, low clouds in the Southeastern Pacific is sensitive to ascent area SST variability on the interannual time scale, indicating a negative cloud feedback. However, this remote pathway becomes weaker in quadrupled CO2 (4xCO2) experiments across CMIP6 models. By contrast, the positive low cloud feedback to local SST remains strong in 4xCO2 warming compared with its strength in observations and piControl. Furthermore, there is a huge decadal variability in the strength of this remote pathway, adding difficulty to constrain model performance based on the short record of recent observations.