Studies of internal wave-driven mixing in the coastal ocean have been mainly focused on internal tides, while wind-driven near-inertial waves (NIWs) have received less attention in this regard. This study demonstrates a scenario of NIW-driven mixing over the Texas-Louisiana shelf. Supported by a high-resolution simulation over the shelf, the NIWs driven by land-sea breeze radiate downward at a sharp front and enhance the mixing in the bottom boundary layer where the NIWs are focused due to slantwise critical reflection. The criterion for slantwise critical reflection of NIWs is (where ω is the wave frequency, Sbot is the bottom slope, and Sp is the isopycnal slope) under the assumption that the mean flow is in a thermal wind balance and only varies in the slope-normal direction. The mechanism driving the enhanced mixing is explored in an idealized simulation. During slantwise critical reflection, NIWs are amplified with enhanced shear and periodically destratify a bottom boundary layer via differential buoyancy advection, leading to periodically enhanced mixing. Turbulent transport of tracers is also enhanced during slantwise critical reflection of NIWs, which has implications for bottom hypoxia over the Texas-Louisiana shelf.